Polymer Chemistry

Dr. Sheta is a Researcher in National Research Centre, Inorganic Chemistry Department, Giza, Egypt. He obtained his B.Sc. and Master’s degrees in Applied Chemistry from Helwan University, Egypt in 2004 and 2010, respectively. He obtained his Ph.D. in Inorganic-Analytical Chemistry from Ain Shams University, Egypt in 2015, he joined the National Research Centre, Egypt in 2013. Technical Manager in Family Medical Laboratory, Giza, Egypt since 2008. He serves as an Editorial board member and reviewer of many international Journals.

In this work a novel copper metal-organic frame works nanoparticles (Cu-MOF-NPs) was synthesized and fully characterized. Cu-MOF-NPs was used for first time as a Nano biosensor for alpha fetoprotein (AFP) quantification as an early test for liver cancer diagnosis photoluminescence (PL) study was carried out for the Cu-MOF-NPs, and the results showed that Cu-MOF-NPs exhibits strong emission at 418 nm after excitation at 354 nm. Moreover, the Stern-Völmer graph shows a linear calibration curve which achieved over a concentration range 1.0 - 520 ng/mL of AFP with a correlation coefficient, 0.997, detection limit 1.18 ng/ mL, and quantitation limit 3.58 ng/mL. According to the remarkable quenching of the PL intensity of Cu-MOF-NPs using various concentrations of AFP, it was successfully used as a biosensor for AFP in serum samples collected from hepatitis A, B and C patient in addition to healthy males and females. The quenching mechanism was well studied, and it has a dynamic type. The present work offers simplicity, low cost, room temperature operation, rapid technique, no consuming time, highly accurate, selectivity, and high sensitivity comparing with most of the published methods.